ABSTRACT

Inammation is an essential component to the host defense against invading microbes. Infection initiates an ampliœed cascade of signals that leads to the recruitment of inammatory cells. Neutrophils and macrophages phagocytose these infectious organisms, release cytokines and chemokines, and activate lymphocytes, which results in adaptive immunity. Since tissue injury frequently involves exposure to the outside environment and potential infection, it is intuitive that inammation developed as a critical component of wound repair.