ABSTRACT
Systemic contact dermatitis (SCD) is a relatively uncommon and poorly understood aspect of allergic contact dermatitis (ACD) that highlights the potential for long-lasting immunologic memory in previously sensitized and nonsensitized areas of the skin. It may occur in persons with contact sensitivity after exposure to the hapten by oral exposure, transcutaneously, intravenously, or by inhalation. The condition can present itself with clinically characteristic features or be clinically indistinguishable from other types of contact dermatitis.
