ABSTRACT
LIQUID SILICONE Liquid silicone (LIS), an inert and biocompatible synthetic polymer, was first used as an injectable filler in the 1950s. Before collagen injectable fillers became available in the early 1980s, LIS was the injectable filler of choice. However, there was no standardized FDA-approved LIS and different products of varying purity were often injected in large bolus form, which led to frequent product migration. Many products were intended for industrial rather than in vivo use, and impurities lead to frequent foreign body reactions. Subsequently, in the early 1990s, all forms of silicone for cosmetic implantation were banned by the FDA, citing possible toxicity and systemic reactions related to LIS and silicone breast implants.
