ABSTRACT
In men, the required dose of botulinum toxin is significantly higher than that needed to treat similar lines in women. A 2005 study by Jean and Alastair Carruthers conducted a randomized control trial of the safety, efficacy, and duration of four different doses of botulinum toxin type A for the treatment of glabellar rhytides in men ( 6 ). The investigators found that doses of 40, 60, or 80 units were consistently more effective than 20 unit doses. Response rate and duration of treatment both showed a dose-dependent increase. Altering the volume of saline used to reconstitute a vial of botulinum toxin was hypothesized to also affect the final outcome ( 5 ).
