ABSTRACT
INTRODUCTION Heparin-induced thrombocytopenia (HIT) can occur in children, with the potential for severe venous and arterial thrombotic complications (Table 21.1). Unlike in adults, few data exist regarding pediatric HIT. Only 116 children have been reported with HIT between 1990 and 2011 (Oriot et al., 1990; Potter et al., 1992; Murdoch et al., 1993; Boon et al., 1994; Klement et al., 1996; Wilhelm et al., 1996; Butler et al., 1997; Schiffmann et al., 1997; Barth, 1998; Sauer et al., 1998; Scurr et al., 1998; Bocquet et al., 1999; Saxon et al., 1999; Weigel et al., 1999; Neuhaus et al., 2000; Ranze et al., 1999, 2001; Girisch et al., 2001, 2002; Severin and Sutor, 2001; Zöhrer et al., 2001; Deitcher et al., 2002; Schmugge et al., 2002; Severin et al., 2002a; Boshkov et al., 2002, 2003a,b, 2004; Gatti et al., 2003; Schlegel and Hurtaud-Roux, 2003; Klenner et al., 2003b, 2004; Newall et al., 2003; Nguyen et al., 2003; Porcelli et al., 2003; Alsoufi et al., 2004; Dager and White, 2004; Lischetzki et al., 2004; Malherbe et al., 2004; Mejak et al., 2004; Rischewski et al., 2004; Tcheng and Wong, 2004; Verso et al., 2004; Frost et al., 2005; Grabowski et al., 2005; Iannoli et al., 2005; John and Hallisey, 2005; Martchenke and Boshkov, 2005; Bidlingmaier et al., 2006; Knoderer et al., 2006; Schreiber et al., 2006; Scott et al., 2006; von Heymann et al., 2006; Potter et al., 2007; Breinholt et al., 2008; Ciccolo et al., 2008; Hanke et al., 2009; Maurer et al., 2009; Dragomer et al., 2011; Pollak et al., 2011).
