ABSTRACT
Globular Pattern Pigmented Spitz nevi often present with a diffuse brownish hue with widely spaced gray-brown, small-to-medium-sized globules (Fig. 7e.9a, b).
In heavily pigmented lesions, globules are brown to bluish to black, large and distributed throughout the lesion or at the periphery (Fig. 7e.10a, b of blue Spitz globular Magipinto). Globular pattern Spitz nevi can also reveal reticular depigmentation (Fig. 7e.11A-D). On occasion, the globules in a Spitz nevus are arranged in a centrifugal fashion and reminiscent of an exploding star (Fig. 7e.12a, b). This pattern differs from the peripheral globular pattern seen in growing Clark nevi (see chap. 7C) in that the globules in a growing Clark nevus are distributed in a single row at the periphery of the lesion. In contrast, in Spitz nevi there are multiple rows of globules (i.e., tiered) at the periphery.
