ABSTRACT

Poison Control Centers (AAPCC) (see Section “Role of the Poison Control Center”).

Predicting the effects of toxic agents in animals is critical and the effects are mandatory facts of human risk management. Basic to understanding human toxicities is the assumption that information gained from animal models can be extrapolated to analogous human situations. Other relevant information, from epidemiology studies and clinical research, is then integrated with the animal data to make regulatory decisions regarding human safety.