ABSTRACT
Lysosomes were thought to be the main site of protein degradation in cells until, in 1970s and early 1980s, a ubiquitin-dependent protein degradation coupled to ATP hydrolysis was discovered and related to the large protein complex called proteasome. Work accomplished by a number of researchers culminated by elucidating the
8.1 Protein Degradation by Proteasomes ............................................................ 137 8.1.1 Proteasome Structure ........................................................................ 138 8.1.2 Targeting for Degradation ................................................................. 139 8.1.3 Proteasome Mechanisms .................................................................. 141
8.2 Protein Degradation by Lysosomes .............................................................. 142 Further Reading ..................................................................................................... 143
main features of the ubiquitin proteasome system and resulted in the Nobel Prize to Hersko, Ciechanover, and Rose in 2004.
