ABSTRACT
Dry heat is one of the most commonly used methods to
sterilize and/or depyrogenate pharmaceutical com-
ponents and products. Dry heat sterilization is often
used for heat-stable oils, ointments and powders. Most
often, depyrogenation of parenteral containers is
performed utilizing a dry heat oven. The depyrogenation
process is also utilized on certain heat-stabile com-
ponents, glass containers, metal equipment, etc. to
render the item and final parenteral product free of
pyrogens. The equipment utilized to provide the dry
heat medium must be validated to ensure that the
system is able to provide sterile and/or depyrogenated
components, on a reproducible basis.
