ABSTRACT
The clinical manifestations of Epstein-Barr virus (EBV) infection depend on factors such as age and state of immunocompetence, and include an astonishing array of multisystemic involvements (see Chapter 6). The neurological manifestations of EBV infection were first noted by Epstein and Dameshek (1), who reported a case of encephalitis, and then by Johansen (2), who reported aseptic meningitis, in patients with acute infectious mononucleosis (IM). Since then, a large number of neurological manifestations of EBV infection that affect both the central nervous system (CNS) and the peripheral nervous system have been documented.
