ABSTRACT

Presenting the first database of its kind, this unique reference illustrates the relationships between the chemistry and developmental toxicity of a number of important pharmaceuticals and industrial toxicants. Human Developmental Toxicants contains up-to-date and concise information on the chemical structures, properties, and biological activities for 50 known agents that adversely affect prenatal and postnatal human development in terms of growth, viability, structure, and function.

This book presents data linking chemical and structural properties of specific toxicants as they relate to toxic effects, dosage, timing, and route of exposure. Focusing on one compound per chapter, the book also includes associated biological data from animals for each agent covered. Accompanying downloadable resources summarize all of the data discussed in the text within an electronic database. In addition, the CD contains three-dimensional structure representations and 49 calculated physicochemical and topological parameters of the selected molecules. This information is useful for building structure activity relationship (SAR) models linking the chemical properties with observed human developmental toxicity.

As scientists continue to explore how chemicals alter human development, Human Developmental Toxicants contains the necessary information to further identify which chemical properties are responsible for adverse effects. This reference provides toxicologists, teratologists, chemists and other scientists with the latest data and information needed to perform risk assessments, predict chemicals that may produce developmental toxicity, and regulate harmful exposure.

chapter 1|6 pages

Aminopterin

chapter 2|4 pages

Busulfan

chapter 3|6 pages

Cyclophosphamide

chapter 4|6 pages

Methotrexate

chapter 5|4 pages

Chlorambucil

chapter 6|4 pages

Mechlorethamine

chapter 7|4 pages

Cytarabine

chapter 8|6 pages

Tretinoin

chapter 9|4 pages

Propranolol

chapter 10|4 pages

Penicillamine

chapter 11|8 pages

Vitamin A

chapter 12|6 pages

Carbamazepine

chapter 13|4 pages

Danazol

chapter 14|4 pages

Paramethadione

chapter 15|6 pages

Carbon Monoxide

chapter 16|4 pages

Formaldehyde

chapter 17|6 pages

Isotretinoin

chapter 18|6 pages

Captopril

chapter 19|6 pages

Misoprostol

chapter 20|6 pages

Streptomycin

chapter 21|6 pages

Methimazole

chapter 22|4 pages

Ethylene Oxide

chapter 23|4 pages

Tetracycline

chapter 24|8 pages

Caffeine

chapter 25|16 pages

Thalidomide

chapter 26|6 pages

Primidone

chapter 27|4 pages

Fluconazole

chapter 28|4 pages

Ergotamine

chapter 29|6 pages

Propylthiouracil

chapter 30|6 pages

Medroxyprogesterone

chapter 31|12 pages

Cocaine

chapter 32|6 pages

Quinine

chapter 33|6 pages

Methylene Blue

chapter 34|10 pages

Warfarin

chapter 35|6 pages

Phenobarbital

chapter 36|4 pages

Trimethoprim

chapter 37|4 pages

Methyltestosterone

chapter 38|4 pages

Disulfiram

chapter 39|12 pages

Valproic Acid

chapter 40|4 pages

Carbon Disulfide

chapter 41|6 pages

Norethindrone

chapter 42|12 pages

Phenytoin

chapter 43|6 pages

Etretinate

chapter 44|8 pages

Toluene

chapter 45|4 pages

Ethisterone

chapter 46|6 pages

Acitretin

chapter 47|4 pages

Valsartan

chapter 48|14 pages

Diethylstilbestrol

chapter 49|4 pages

Pseudoephedrine

chapter 50|22 pages

Ethanol

chapter 51|12 pages

Discussion and Summary