ABSTRACT

Introduction............................................................................................................397 The Blood-Brain Barrier .......................................................................................398 Structure and Function of the Blood-Brain Barrier..............................................401 Development and Ontology of the Blood-Brain Barrier ......................................406 Transport Across the Blood-Brain Barrier ............................................................407 The Blood-Brain Barrier and the Delivery of Centrally Active Drugs ................410 Pathology of the Blood-Brain Barrier in Lysosomal Storage Disease.................414 Conclusions............................................................................................................416 References..............................................................................................................417