ABSTRACT
In contrast to the standard technique of histopathology of mechanically-removed, sliced, and stained biopsies, noninvasive three-dimensional (3D) high-resolution imaging has the advantages of (i) providing a painless method without tissue removal, (ii) access to fast (immediate) information, (iii) the examination under natural physiological in vivo conditions, and (iv) the possibility of long-term studies on the same tissue area. Long-term studies are of particular interest for in vivo drug screening and the monitoring of therapeutic effects.
