ABSTRACT
Approaches to its Management.....................................................395 14.2.3 Local Drug Delivery......................................................................396 14.2.4 Staphylococcus aureus Osteomyelitis — Special
Considerations for Treatment ........................................................400 14.3 Evolution in Bone Infection Management and Development
of New Controlled Drug Delivery Systems ...............................................401 14.3.1 Controlled Release Systems Using Traditional Absorbable
and Water-Soluble Polymers .........................................................401 14.3.2 Controlled Release of Antibiotics from Absorbable
Gel-Forming Formulations ............................................................403 14.3.3 Advances toward New Approaches to the Treatment
of Osteomyelitis.............................................................................405 14.4 Conclusion and Perspective on the Future .................................................407 References..............................................................................................................407
Osteomyelitis is a bacterial infection involving bone that is characterized by progressive inflammatory destruction of bone tissue. And while much progress has been made with regards to antibiotic development and the prevention of postsurgical
bone infection, osteomyelitis remains a significant cause of morbidity. Osteomyelitis may be the result of hematogenous seeding of bacteria, spread of infection from a contiguous area, surgical inoculation of bacteria into bone, or trauma coincident with contamination.
