ABSTRACT
Regulation of gene expression plays a fundamental role in many normal and abnormal cellular physiological processes, including normal cell differentiation and development, carcinogenesis, and host responses to many environmental insults and pathological changes. Identification of genes that are differentially expressed in different cell types or under various conditions is of great importance in modern biology. Traditionally, differential hybridization and subtractive hybridization have been used widely to identify genes that express differentially between different but closely related types of cells or tissues.
