ABSTRACT
CASRN: 68-12-2; DOT: 2265; DOT label: Combustible liquid; molecular formula: C3H7NO; FW: 73.09; RTECS: LQ2100000; Merck Index: 12, 3292 Physical state, color, and odor: Clear, colorless to light yellow, hygroscopic, mobile liquid with a faint, characteristic, ammonialike odor. An experimentally determined odor threshold concentration of 100 ppmv was reported by Leonardos et al. (1969). Melting point (°C): -60.5 (Weast, 1986) Boiling point (°C): 153.00 (Blanco et al., 1997) Density (g/cm3): 0.94862 at 20.00 °C (Houkhani et al., 2000) 0.9449 at 25.00 °C, 0.9394 at 30.00 °C, 0.9347 at 35.00 °C (Aralaguppi et al., 1997) 0.94119 at 30.00 °C (Ramadevi et al., 1996) Diffusivity in water (x 10-5 cm2/sec): 1.03 at 20 °C using method of Hayduk and Laudie (1974) Flash point (°C): 57.8 (NIOSH, 1997) 67 (open cup, Windholz et al., 1983) Lower explosive limit (%): 2.2 at 100 °C (NFPA, 1984) Upper explosive limit (%): 15.2 (NFPA, 1984) Ionization potential (eV): 9.12 ± 0.02 (Franklin et al., 1969) Soil organic carbon/water partition coefficient, log Koc: Unavailable because experimental methods for estimation of this parameter for aliphatic amines are lacking in the documented literature. However, its miscibility in water and low Kow suggest its adsorption to soil will be nominal (Lyman et al., 1982). Octanol/water partition coefficient, log Kow: -0.82 at 25 °C (shake flask-GLC, Park and Park, 2000) -0.25 at 20-25 °C (shake flask-GC, Wolosin et al., 1978)
Miscible with most organic solvents (Windholz et al., 1983) Solubility in water: Miscible (NIOSH, 1997). A saturated solution in equilibrium with its own vapor had a concentration of 5,294 g/L at 25 °C (Kamlet et al., 1987). Vapor density: 2.99 g/L at 25 °C, 2.52 (air = 1) Vapor pressure (mmHg): 3 at 20 °C (NIOSH, 1997) 3.7 at 25 °C (Sax and Lewis, 1987) Environmental fate: Biological. Incubation of [14C]N,N-dimethylformamide (0.1-100 µg/L) in natural seawater resulted in the compound mineralizing to carbon dioxide. The rate of carbon dioxide formation was inversely proportional to the initial concentration (Ursin, 1985). Chemical. Reacts with acids or bases forming formic acid and dimethylamine (BASF, 1999) Exposure limits: NIOSH REL: TWA 10 ppm (30 mg/m3), IDLH 500 ppm; OSHA PEL: TWA 10 ppm; ACGIH TLV: TWA 10 ppm (adopted). Toxicity: EC50 (24-h), EC50 (48-h), LC50 (24-h), and LC50 (48-h) values for Spirostomum ambiguum were 9.87, 8.19, 31.7, and 19.7 g/L, respectively (Nałecz-Jawecki and Sawicki, 1999). Acute oral LD50 for mice 3,750 mg/kg, rats 2,800 mg/kg (quoted, RTECS, 1985). Uses: Solvent for liquids, gases, vinyl resins, wire enamels; polyacrylic fibers; gas carrier; catalyst in carboxylation reactions; organic synthesis (manufacture of aldehydes, amides, amines, esters, heterocyclics).
