chapter  13
24 Pages

BHE/Cdb Rats as Tools to Study Mitochondrial Gene Expression

The BHE/Cdb Rat ................................................................ 582 Colony Development ............................................................ 583 The BHE/Cdb Rat as a Model for the Nonobese

Type 2 Diabetic Humans ............................................ 586 Thyroid Hormone Affects the Metabolic Features of

the BHE/Cdb Rat ........................................................ 587 Genetic Studies .................................................................... 589 Longevity Studies................................................................. 594 Vitamin A.............................................................................. 594 Summing Up......................................................................... 596 References............................................................................. 597

THE BHE/CDB RAT

The BHE/Cdb rat strain was developed as an inbred strain designed for the study of maturity onset diabetes.* The original strain, the BHE strain, was developed through a cross of the Osborne Mendel strain and the now nonexistent Pennsylvania State College strain. Scientists at the Bureau of Home Economics (thus the BHE name for the strain) were part of the USDA research facility at Beltsville, Maryland.