ABSTRACT
I. Molecular Imaging Strategies 286
A. Direct Imaging 286
B. Indirect Imaging 288
C. Biomarker Imaging 291
II. Oncogenic Cell Transformation 293
A. The Study of Lung Cancer in Experimental Mouse Models 295
B. Genetic Mouse Models of Lung Cancer 295
III. Imaging Oncogenesis in Genetic Mouse Models 297
IV. Imaging Oncogenesis Pathways 298
V. Imaging Tumor Treatment 303
Acknowledgments 305
References 305
Medical imaging has undergone a remarkable revolution and expansion in the
past two decades. This is largely due to improved imaging technology involving
all the major imaging modalities: magnetic resonance (MR), computed tomogra-
phy (CT), positron emission tomography (PET), ultrasound and optical imaging.
These advances and improvements in technology are being rapidly translated into
the clinic and have established new standards of medical practice. For example,
“Cancer imaging” was identified as one of six “extraordinary scientific
opportunities” by the National Cancer Institute (NCI) in 1997-1998, and sub-
sequent funding initiatives from NCI have provided a major stimulus for
further developments. A major component of this imaging initiative included
the development and support for molecular imaging.
