ABSTRACT
Introduction ......................................................................................................................................99 Rationale behind the in Vitro Models Used in Diabetes Research...............................................101 Models to Study Inhibition of Carbohydrate-Digesting Enzymes................................................102 Models to Study Inhibition of Intestinal Glucose Uptake ............................................................103 Models to Study Insulin Secretion from β-Cells of the Pancreas ................................................105 Models Based on the Liver as an Insulin Target Tissue ...............................................................106 Models Based on Adipocytes as an Insulin Target Tissue............................................................108 Models Based on Muscle as an Insulin Target Tissue ..................................................................109 Interactions with the Insulin Receptor ..........................................................................................109 Glucagon Receptor Antagonists.....................................................................................................110 Practical Considerations.................................................................................................................110
