ABSTRACT
Disorders of leukocytes can be classified into two groups, a malignant or neoplastic and a benign or reactive type. Benign disorders can be further subclassified into two groups, quantitative disorders and qualitative disorders. Qualitative disorders of leukocytes are characterized by either abnormal leukocyte morphology with or without functional abnormality or are associated with abnormal leukocyte function with or without morphologic abnormality. The abnormalities, morphologic and functional, may involve any one or more types of leukocytes and may be inherited or acquired. Neutropenia may be selective or part of a general pancytopenia, which refers to a reduction in all three cell lines, leukocytes, erythrocytes, and thrombocytes in the peripheral blood. Alder-Reilly anomaly is a rare autosomal recessive disorder characterized by the presence of larger than normal azurophilic granules in the cytoplasm of leukocytes and macrophages of the blood and bone marrow. Monocytosis is often transient and correlates poorly with specific disorders.
