ABSTRACT
Although the sequence of molecular and cellular events following cerebral ischemia is highly complex, research over the last decades has revealed that ischemia induced pathophysiology appears to follow a stereotypic, spatio-temporal pattern. In this chapter we will review those events, with particular emphasis on the ischemic penumbra. Conceptually, we will treat ischemia-induced pathobiology as a cascade of interlinked mechanisms, which ultimately lead to either cell death or survival.
