ABSTRACT
Although many local factors contribute to a fine balance maintained in the eye between prevention of inflammation and promotion of immune protection, anterior chamber associated immune deviation (ACAID) represents an active phenomenon that induces a systemic effect that is involved in maintaining the immune-privileged status of the eye. Antigens introduced in the anterior chamber of an eye invoke a unique systemic immune response that is distinct from a conventional immune response. This immune response to ocular antigens differs from a conventional response in that it is deficient in pro-inflammatory (Th1) effectors and complement fixing antibodies (IgG2a) (1) that are potentially detrimental to the ocular tissue.
