ABSTRACT
This chapter reviews the role of genetics in the development and progression of coronary artery disease (CAD), the available genetic risk assessment strategies for CAD, and clinical application of genetic risk information for CAD prevention. Several studies have identified a strong association between the platelet glycoprotein receptor IIIa A2 allele and extensive CAD or occurrence of coronary thrombosis. 5-lipoxygenase converts dietary fatty acids to leukotrienes, potential inflamma-tory mediators of atherosclerosis. An important goal of genetic evaluation for CAD is the development of individualized preventive strategies based on the genetic risk assessment, and the patient’s personal medical history, lifestyle, and preferences. Several lines of evidence support the contribution of genetic variations to the development and progression of CAD, and to response to risk factor modification and lifestyle choices. Additional information from the medical history, physical examination, biochemical, and DNA testing, interpreted in the context of the family history, can further refine the genetic risk assessment.
