ABSTRACT
In less than two decades, human immunodeficiency virus (HIV) has dramatically progressed from a little-known or understood infection to the cause of a major global epidemic. In 1998,36 million people were infected worldwide (1). Today, more than 46 million people are infected worldwide, with 16,000 new infections occurring in the world each day. Ninety-five percent ofthe HIV-infected population lives in the undeveloped-to-developing world where adequate treatment and prevention programs are lacking. For instance, the majority of new HIV infections in 2003 occurred in sub-Saharan Mrica, where even monotherapy for HIV is lacking.
