ABSTRACT
Chromatography (HPLC)...............................................................................94 3.9.1 HPLC with Octanol-Coated Columns ...............................................96 3.9.2 Other Methods using Octanol-Coated Columns .............................100 3.9.3 ELogP Method .................................................................................100 3.9.4 Reversed-Phase HPLC (RP-HPLC).................................................102 3.9.5 The extrapolation method, logkw .....................................................102 3.9.6 Isocratic logk Values ........................................................................105 3.9.7 The Significance of Slope S ............................................................106 3.9.8 Correction for Ionization .................................................................107 3.9.9 The Influence of Stationary Phase on Lipophilicity
Measurements...................................................................................108 3.9.10 Mobile Phase Composition and Lipophilicity.................................112
