ABSTRACT
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Fanne sperientia e poi regola. (‘‘Make experiments and then the rule.’’) 51r (c. 1499)
Leonardo da Vinci, Madrid Codex I
The symbiosis between experiment and theory is well known; likewise, the
advancement of chip-based analytical instruments relies in part on new tools
for diagnosing them. As microfabrication offers us unprecedented control
over the geometry and surface chemistry of our devices, transport phenomena
that were previously negligible can become dominant, and thus, new tech-
niques for observation and theory evaluation have recently been developed.
This chapter focuses on such techniques for diagnosing the performance of
microfluidic systems: novel fluorescence imaging techniques, microparticle
imaging velocimetry (m-PIV), and numerical simulation.
