ABSTRACT
Metabolism (M) and toxicokinetic studies constitute a part of the overall toxicological
evaluation of chemicals. Studies are designed to obtain information on the fate of the
compound in the organism; therefore, they focus more on the behavior and less on the effect
of the compound. The information developed permits a more complete understanding of
the relationship between chemical exposure and toxicity. The focus of this chapter is
toxicokinetic study design, data analysis, and data interpretation, as applied to the
understanding of health effects, with particular reference to regulatory guidelines.
