ABSTRACT

The term “epigenetics”—from “epi” the Greek for “above”—was first coined in the 1940s by Conrad Waddington, who defined epigenetics as “the causal interactions between genes and their products which bring phenotype into being” (1). The term “epigenetics” is now used to refer to stably maintained mitotically (and potentially meiotically) heritable patterns of gene expression occurring without changes in DNA sequence.