ABSTRACT
Proteomics, the comprehensive analysis of a protein complement in a cell, tissue, or biological fluid at a given time, has been enabled by quantum leaps in mass spectrometric technology, which allowed identification of large, involatile biomolecules. Over the last two decades, this discipline evolved from the sole delivery of protein identities to a platform that reveals clues to function through quantitative proteomics, i.e., the global comparison of protein amounts between two defined biological states, and the characterization of protein modifications and interactions.
