ABSTRACT
Gold has been used for immunocytochemistry since 1971 when Faulk and Taylor discovered adsorption of antibodies to colloidal gold.5 It is an ideal label for electron microscopy (EM) due to its high atomic number, which scatters electrons efficiently, and the fact that preparative methods have been developed to make uniform particles in the appropriate size range of 5 to 30 nm.16 Use in light microscopy (LM) generally requires silver enhancement (autometallography; AMG) of these small gold particles.
