ABSTRACT
The study of epigenomics includes the analysis of changes in DNA methylation and histone protein modification states. Recent technical advances allow analysis of epigenetic features in a high-throughput manner. This has resulted in accelerated discovery of candidate disease-causing epigenetic changes and fueled development of novel epigenetic therapeutics. We describe the current understanding of the role epigenomics plays in normal developmental processes and tumorigenesis; we address the current technologies for analyzing these changes.
