ABSTRACT
Mass spectrometer (MS) is considered the most powerful detector for liquid chromatography (LC), though only after the development of “soft” ionization techniques LC and MS were brought closer, and powerful instrumentations have permitted new challenging analytical applications. Although the coupling of LC and MS is a chemically and physically challenging operation and its practical application is still far from the immediacy and simplicity of gas chromatography (GC)-MS, it opens the door for the determination of large and thermally labile molecules in complex matrices.
