ABSTRACT
Resveratrol is the key ingredient found in grapes, berries, and peanuts, and more than 70 species of plants contain this phenolic antioxidant. Resveratrol is most prevalent in the skin of grapes, and its presence in wine is thought to account for the fact that wine drinkers appear to have a lower risk for heart disease. Cancer-preventing action by certain human nutrients derived from plants and fruits has been confirmed in various cell cultures and animal tumor models. Numerous studies provide evidence for the anticarcinogenic activity of resveratrol, but the precise mechanisms involved in the modulation of oncogenic precursors of prostate carcinogenesis remain to be elucidated. Exploring transcriptional and posttranslational modification of target genes and proteins modified by resveratrol may provide more insight into the differences in RNA versus protein expression. Dietary factors that influence DNA methylation and the risk for cancer development are evident from preclinical and clinical studies.
