ABSTRACT
The immunomodulatory effects of resveratrol, primarily on the generation of cellmediated cytotoxicity and cytokine production, have been published in scattered reports. The inhibition or augmentation of the proliferative response of lymphocytes is frequently used to evaluate potential therapeutic agents for their immunomodulatory effects. Resveratrol inhibits tetradecanoyl phorbol-13-acetate-induced free radical formation in human leukemia-60 leukemic cells in a dose-dependent manner. The effect of oral administration of resveratrol on various lymphoid populations in different lymphoid tissues has been evaluated by independent investigative teams. In general, cytokine production is enhanced at low concentrations and suppressed at high concentrations of resveratrol; however, additional studies are needed to establish the in vivo effect of resveratrol on cytokine production. More research is required to establish thoroughly the immunomodulatory properties of resveratrol and their mechanism of action. Resveratrol modulates the production of cytokines by monocytes and macrophages.
