ABSTRACT
The concept that tumor growth is dependent on angiogenesis and that suppression of neovascularization may be used for cancer therapy. Resveratrol has been described as preventing tumor initiation, as well as tumor promotion and progression, making it a putative chemopreventive and therapeutic agent for use against cancer. The antiendothelial effects of resveratrol have been investigated in vitro using various different assays and cell lines, including human umbilical vein endothelial cells, bovine adrenocortical capillary endothelial cells, bovine pulmonary artery endothelial cells, bovine aorta endothelial cells, and porcine aorta endothelial cells. Several cardioprotective effects have been ascribed to resveratrol, including antiinflammatory, profibrinolytic, and antiadhesive effects on the endothelium. The antiadhesive endothelial effect of resveratrol has been investigated in vitro in response to potent stimulators. Resveratrol has antiproliferative effects in a number of different cell types, including endothelial cells, lymphocytes, fibroblasts, and many tumor cell lines.
