ABSTRACT
Common vaccines show, besides their prophylactic effect, quite often unfavorable side effects with symptoms such as pain, swelling, and inflammation. These effects can be traced back to the use of aluminum-based salts as adjuvant. During the last two decades, a variety of new adjuvants have been investigated to replace the widely used aluminum salts. However, only two new adjuvants were approved by regulatory authorities in the last 20 years. One of them is an immunopotentiating reconstituted influenza virosome, which is a potent adjuvant without showing any unfavorable effects . Additionally, virosomes stand apart from all other adjuvants by their capability as an antigen carrier. A wide variety of antigens including peptides, proteins, carbohydrates, and nucleic acids can be delivered by them.
