chapter  9
42 Pages

Use of Neurotoxins as Drug Delivery Systems

Anticipated for Cargos Linked to BoNT-or TeNT-Based Vehicles ...........240 9.11 Conclusions ..................................................................................................241 References..............................................................................................................242

Clostridial neurotoxins that have been rendered innocuous possess several unique functional activities that potentially suit them for transport of foreign cargos across anatomical barriers to a variety of locations in the nervous system. This chapter reviews the varied approaches used to generate nontoxic fragments or engineer other important recombinant derivatives of botulinum (BoNT) and tetanus neurotoxin (TeNT) in order to exploit the potent neuron targeting and delivery capabil-