chapter  10
26 Pages

Conclusions and Future Perspectives: Botulinum Neurotoxins as Paradigms for Development of Microbial Effector- Derived Drugs

Approaches to Modifying Cell Function.........................................258 10.2 To Kill or Not to Kill: Strategies for Toxin Therapeutics ..........................265

10.2.1 Killing Cells for Therapy.................................................................265 10.2.2 Targeting of Small GTPases by Bacterial Effectors: Strategy

for Modulating Cell Signaling.........................................................267 10.2.3 Modifying Immune Response as Therapeutic Strategy ..................270 10.2.4 Delivery of Therapeutic Molecules to Cells ...................................272

10.3 General Themes for Future Development of Bacterial Effector-Based Therapeutics ........................................................................272

References..............................................................................................................273