ABSTRACT

I. Introduction ....................................................................................242 A. Historical Perspective of Genotoxicity and

Genetic Ecotoxicology............................................................242 B. Genotoxic Compounds and Agents in the Environment ...243 C. Linking the Mechanism of Genotoxicity with

Its Consequences ....................................................................244 II. The Use of Reptilian Species in the Study of Aquatic and

Terrestrial Genotoxicity.................................................................246 A. Biomarkers of Exposure and Effect in

Reptilian Populations ............................................................249 1. DNA Damage as a Biomarker of Exposure ...............249 2. Neoplasia as a Biomarker of Effect..............................251

III. Reptilian Models for Studies of Genotoxicity...........................252 A. Chelonia ...................................................................................252