ABSTRACT
Early vulvar cancer is effectively treated with surgery alone or in combination with radiotherapy. Unfortunately, 5-year survival in patients with advanced and recurrent is still disappointing. Half of these patients die within 1-3 years. Most patients with lymph node involvement are treated with surgery with or without adjuvant radiotherapy (1). There is no evidence that chemotherapy alone has a curative role in this tumor. The possible role of chemotherapy in combination regimens is still to be defined. We are going to discuss the possible application of chemotherapy for the management of these tumors. In particular, we will discuss the role of neoadjuvant chemotherapy, neoadjuvant chemoradiotherapy, chemoradiotherapy as sole treatment, adjuvant chemoradiotherapy, and chemotherapy alone.
