ABSTRACT
These viral infections are extremely frequent and show a tendency to recurrences. It has been reported that herpes labialis (HSV-1) affects almost 50% of the population of the United States and more than 25% of the infected individuals often have severe recurrent infections (U.S. Department of Health 1980). Every year 19 million people are infected in France. In Bulgaria (Karagyozov et al. 1989) genital herpes is presently manifested as an epidemic sexually transmitted disease. The problem with genital herpes (and with herpes 1 infections) is the high frequency of recurrences, which are due to a latent form of the virus in the sensory neural ganglia. These patients usually have insufficiencies in their cellular immunity. On average genital herpes can recur four times a year in 80 to 90% of patients who have been infected once (Corey et al. 1983).
