chapter  2
16 Pages

Interferon gamma

The different receptors and the differences in the metabolic signaling pathways open avenues for a combined clinical use of IFN

γ

and IFN

β

(Schiller et al. 1986, 1987, 1990a,b) or IFN

γ

and IFN

α

(Brunda and Wright 1986). In the latter case, the possible effect of IFN

γ

on the IFN

α

receptor has to be taken into consideration. This effect seems to depend on the cellular type. In the neuroblastoma cell line T98G, IFN

γ

suppresses the binding of IFN

α

to its receptor, possibly by affecting its dissociation constant (Kd) (Hannigan et al. 1984). In other tumor cell lines (melanoma HMV-1, kidney carcinoma ACHN, Daudi lymphoma), IFN

γ

induces the receptors of IFN

α

but only under the condition that IFN

γ

preceded the treatment with IFN

α

(Ishii and Tsukagoshi 1989).