ABSTRACT
An important advantage of solid-phase organic synthesis (SPOS) is that it circumvents tedious intermediate isolation and purification procedures, such as recrystallization, distillation, and chromatography. Ideally, a solid-phase reaction can be driven to completion by excess reagent without causing problems during purification. In reality, most organic reactions cannot easily go to completion. Unlike solution synthesis, the resin-bound synthetic intermediate in SPOS cannot be purified. The unreacted portion will accumulate until the end of the synthetic reactions and cause purity problems for the final product. Therefore, onresin quantitative analysis of solid-supported compounds at intermediate stages is very advantageous in guiding the multistep synthesis (Kay et al. 2000; Gaginni et al. 2004).
