ABSTRACT
References 173
1. INTRODUCTION
Obstruction of aqueous outflow causing raised intraocular pressure (IOP) following
trabeculectomy is usually regarded as a surgical complication. Although undesired, it is
in fact the normal and appropriate response to a penetrating eye injury. Wound healing
is a fundamental biological process that is critical for survival. In most living organisms,
wound-healing systems are very well developed. Establishment of prolonged trans-scleral
aqueous flow sufficient to maintain a steady-state pressure gradient of just the right size
represents a highly abnormal state and can only be achieved by inducing a partial
failure of normal wound-healing responses.
