ABSTRACT
I. Introduction .................................................................................................................... 283
II. Albumin Modifications with Heparin for Surface Coatings ......................................... 284
A. Immobilization of Albumin-Heparin Conjugates ................................................. 284
B. Surface Coating by Layer-by-Layer Assembly of Albumin and Heparin ............ 284
C. Surface Coating by Polymerized Mixed Heparin-Albumin ................................. 285
III. Albumin-Cross-Linked Gels .......................................................................................... 286
A. PEG Hydrogels Cross-Linked with Albumin ........................................................ 286
B. Vinyl Polymer Hydrogels Cross-Linked with Albumin ........................................ 288
C. Cross-Linked Heparinized Albumin Gels .............................................................. 289
IV. Albumin Modifications for Nano/Microspheres ............................................................ 289
A. Microspheres of Albumin-Heparin Conjugates .................................................... 290
B. Nanospheres of Surface-Modified Albumin with PEG ......................................... 290
V. Albumin Modifications for Carrier Systems .................................................................. 290
VI. Fabrication of Albumin Wafers Using a Coaxial Ultrasonic Atomizer ........................ 291
A. Principles of Ultrasonic Atomization ..................................................................... 291
B. Fabrication of Albumin Wafers Using a Coaxial Ultrasonic Atomizer ................ 292
VII. Summary ......................................................................................................................... 293
Acknowledgments ....................................................................................................................... 294
References ................................................................................................................................... 294
Albumin is the most abundant protein in plasma. Albumin concentration is about 40 mg/ml, while
the total protein concentration in plasma is about 70 mg/ml. The structure and physicochemical
properties of human serum albumin (HSA) have been well characterized.
