ABSTRACT
High-throughput (HT) structural biology is making significant contributions to our attempts at developing a complete understanding of biological systems. Process pipelines designed using HT approaches have now been implemented to explore
protein fold/function space (Protein Structure Initiative),1,2 to accelerate the Structure Based Drug Discovery (SBDD) process,3,4 to study complete proteomes,5 and to develop and disseminate methods and technologies for working with integral membrane proteins.6 Although HT structure determination was initially designed and used by structural genomics efforts, HT tools and protocols are increasingly being used successfully by individual investigator laboratories. This has been made possible by the development of the various gene-to-structure technologies initiated in the late 1990s and by the commercialization and competition of the technologies between 2000 and 2005 that have lowered the price of these instruments significantly.
