ABSTRACT

Employing a wide range of examples from G-protein-coupled receptors and ligand-gated ion channels, this detailed, single-source reference illustrates the principles of pharmacological analysis and receptor classification that are the basis of rational drug design.
Explains the experimental and theoretical methods used to characterize interactio

chapter |6 pages

Introduction

chapter 1|11 pages

The Characterization and Classification

chapter |7 pages

CELLULARcf J t ? -

chapter |3 pages

gi so

chapter |1 pages

a= [Ah oR/[ A the ratio of the midpoint

a< above it when a> 1, and will lie on the abscissa when a= 1. Thus

chapter |5 pages

n (equivalent

chapter 3|10 pages

Quantification

Interactions Using Binding Methods

chapter |1 pages

Lazareno

+ asymptote

chapter |18 pages

= -nsb)*exp(-kc.rr*t) + nsb

chapter 4|28 pages

Drug Analysis Based

Signaling Responses to G-Protein-Coupled Receptors

chapter 5|21 pages

The Use of Electrophysiology to Improve Understanding of Drug-Receptor Interactions

to Improve Understanding Drug-Receptor Interactions

chapter |7 pages

REFERENCES

chapter |13 pages

Jack

chapter |13 pages

Jack

chapter |22 pages

IBID

chapter 8|8 pages

Histamine H -Receptor Antagonists

chapter VI|4 pages

DEVELOPMENTS SINCE CIMETIDINE

chapter 9|1 pages

AngiotensinAntagonists

chapter 10|12 pages

a-AdrenoceptorAgonistsandAntagonists

chapter |10 pages

(ab) subtype in both native and

chapter 11|20 pages

P u-Purinoceptor Agonists

Emerging Therapy for Pulmonary Diseases

chapter 12|8 pages

Muscarinic Receptor Antagonists

Pharmacological and Therapeutic Utility

chapter |8 pages

CONCLUSION

chapter 13|13 pages

NMDA Receptor Antagonists

chapter |8 pages

CONCLUSION

chapter |4 pages

IJzerrnan et al.

chapter |9 pages

IJzerman et al.

chapter |15 pages

inducing a conformational