ABSTRACT
Figure 8 Schild analysis: homogenous receptor system. Antagonism of the 132adrenoceptor-mediated relaxant effects of isoprenaline by the competitive antagonist ICI 118, 551, in the guinea pig isolated trachea. The data shown is from a single experiment. In each tissue (a-e), the first isoprenaline E/(A] curve performed was a control (0); the second, was in the presence of ICI 118,551 at concentrations of 3 nM (e), 10 nM (D.), 30 nM (A), 100 nM (D), and 300 nM <•>· Note the concentration-dependent parallel rightward displacement of the control curves. (f) illustrates these displacements (r values) in Schild plot form. The plot has a stope of unity and the intercept on the X-axis yields an estimate of 9.24 for the pK8 ( -log10K8 ).
