chapter  59
Novel Risk Markers for Atherosclerosis
Pages 9

Cardiovascular risk assessment is a necessary first step prior to implementing preventive and therapeutic interventions. Two algorithms for cardiovascular risk stratification are recommended in the National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III guidelines.The first algorithm involves counting major risk factors and then estimating the 10-year probability of coronary artery disease (CAD) based on an equation derived from the Framingham Study. The second algorithm identifies the presence of the metabolic syndrome.These predictive models have less than desired accuracy in predicting CAD risk in an individual subject, in part because of the widespread prevalence of conventional risk factors in the general population. Thus, although most patients who suffer a cardiovascular event will have one or more of the conventional risk factors, so do many subjects who do not have CAD.