ABSTRACT
GABA amino acid is thought to be one of the major inhibitory neurotransmitters present within the vertebrate central nervous system (CNS). Almost all brain structures contain GABAergic efferent and local neurons. In 1950, two initial studies [1,2] identified the presence of GABA, the principal inhibitory amino acid, in the vertebrate brain. The inhibitory neurotransmission function of this substance was first demonstrated in the neuromuscular junction in crustacea [3]. In addition, GABA had been shown to satisfy all of the classic criteria of a neurotransmitter [4].
